Outcomes

Since our inception, we consistently and considerably expanded our ability to produce rigorous outcomes research. In 2018, we established more formal leadership for our group and completed 31 research projects, participated in 19 poster presentations and published in 6 third-party journals. Below are highlighted outcomes from studies completed in recent years.

Hepatitis C

Appropriate Management of Drug Interactions Results in Safe Use of Hepatitis C Therapies in Heart Transplant Recipients

A growing number of institutions are usingHCV-positive donor hearts for transplant inHCV-negative recipients. While results of this practice have proven to be successful, management of drug-drug interactions between transplant medications and direct acting antivirals (DAAs) is necessary to ensure safety and efficacy. This study reviews the frequency and type of drug-drug interactions and appropriate management strategies.

To be presented: The International Society for Heart & Lung Transplantation, April 2019
Download Poster (link coming soon): Boyle K, Edmonds C, Schlendorf K, Gray J, Lindenfeld J, Pollack A, Fowler R. Appropriate Management of Drug Interactions Results in Safe Use of Hepatitis C Therapies in Heart Transplant Recipients.

Lipidology: PCSK9 Inhibitors

Multiple Sclerosis

Specialty Medication Adherence

Adherence to Specialty Medications: Assessing rates and correlates of nonadherence at an integrated specialty pharmacy

This study analyzed rates and correlates of medication nonadherence in 7,297 unique prescription/generic product identifiers prescribed specialty medication at an integrated specialty pharmacy in an academic health center. Median PDC of the sample was 99%; 14% of the sample (n=1027) was classified as nonadherent. Nonadherence was more common in women and nonadherent patients were significantly younger than adherent patients.

To be presented: AMCP Annual Meeting, San Diego CA, March 2019
Download poster (link coming soon): : Cherry E, Jolly J, Peter M, Zuckerman A. Adherence to Specialty Medications: Assessing rates and correlates of nonadherence at an integrated specialty pharmacy.

Osteoporosis

Oncology

A Targeted Approach to Reducing Rates of Discontinuation and Dose Reduction in Patients Receiving Sorafenib or Regorafenib
*Gold ribbon abstract winner*

Sorafenib and regorafenib are oral multikinase inhibitors used to treat some cancers, but adverse events for both drugs are common and often cause patients to discontinue therapy or reduce their dose within several months of initiating therapy. This study found that a pharmacist-initiated tailored intervention reduced sorafenib and regorafenib discontinuations (29% to 13%) and dose reductions due to adverse reactions (18% to 13%).

To be Presented: Association of Managed Care and Specialty Pharmacy Annual Meeting, San Diego CA, March 2019
Download Poster (Link coming soon): Looney B, Lamb C, Peter M, Zuckerman A, Nix R. A Targeted Approach to Reducing Rates of Discontinuation and Dose Reduction in Patients Receiving Sorafenib or Regorafenib.

Transplant

Development of a Collaborative Pharmacy Practice Agreement to Improve Efficiency and Management of Prescribing in a Renal Transplant Clinic
*Gold ribbon abstract winner*

Post-transplant patients require complex medication regimens to ensure the survival of the transplanted organ and patient overall well-being. These regimens are frequently adjusted, initiated, or discontinued within soon after transplant. Pharmacist expertise can be utilized to optimize post-transplant medication use. This study describes the creation and corresponding outcomes of a Collaborative Pharmacy Practice Agreements (CPPA) between pharmacists and physicians within a renal transplant clinic.

To be Presented: Association of Managed Care and Specialty Pharmacy Annual Meeting, San Diego CA, March 2019
Download Poster (Link coming soon): Chelewski R, Johnson K, Declerq J, Choi L, Peter M, Langone A, Zuckerman A. Development of a Collaborative Pharmacy Practice Agreement to Improve Efficiency and Management of Prescribing in a Renal Transplant Clinic. To be presented at AMCP Annual Meeting 2019. San Diego, California, March 25-28, 2019.